Rheumatoid Arthritis & Gout MCQ Quiz- GPAT Pharmacist NIPER DIMCQ Quiz-Pharmacy Total No of MCQ; .. 536 Created by SS JakharPharmacology Rheumatoid Arthritis & Gout MCQ Quiz 1 / 23 Category: rheumatoid arthritis and gout The most common effect of colchicine which is dose limiting is: a. Diarrhea b. Dyspepsia c. Retinal damage d. Loss of taste sensation 2 / 23 Category: rheumatoid arthritis and gout Which of the following disease modifying anti-rheumatic drugs (DMARDs) is the drug of first choice? a. Methotrexate b. Gold compounds c. D-penicillamine d. Anakinra 3 / 23 Category: rheumatoid arthritis and gout Leflunomide is used in the treatment of a. Rheumatoid arthritis b. Dermatomyositis c. Bony metastasis d. Postmenopausal osteoporosis 4 / 23 Category: rheumatoid arthritis and gout Allopurinol specifically inhibits a. Xanthine oxidase b. Arginase c. Carbamoyl transferase d. Urease 5 / 23 Category: rheumatoid arthritis and gout Loading dose of leflunomide in rheumatoid arthritis is a. 20 mg b. 10 mg c. 100 mg d. 4000 mg 6 / 23 Category: rheumatoid arthritis and gout Drug useful for gout a. Pyrazinamide b. Rifampicin c. Allopurinol d. Naloxone 7 / 23 Category: rheumatoid arthritis and gout Probenecid interacts with? a. Streptomycin b. Ampicillin c. Vancomycin d. Erythromycin Interactions of Probenecid It competitively blocks active transport of organic acids at all sites especially renal tubules. It inhibits excretion of penicillin/ampicillin and increases its blood level. It also inhibits urinary excretion of cephalosporins, sulfonamides, methotrexate and indomethacin. It inhibits tubular secretion of nitrofurantoin. Salicylates, pyrazinamide and ethambutol inhibit uricosuric action of probenecid. It inhibits biliary excretion of rifampicin. 8 / 23 Category: rheumatoid arthritis and gout Allopurinol potentiates the action of a. Corticosteroids b. Probenecid c. 6-Mercaptopurine d. Ampicillin Allopurinol inhibits xanthine oxidase, which metabolises 6-MP and azathioprine, so dose of 6-MP is reduced to ¼-½ if used along with allopurinol. 9 / 23 Category: rheumatoid arthritis and gout Which of the following drugs is useful in acute attack of gout? a. Furosemide b. Sulfinpyrazone c. Allopurinol d. Piroxicam 10 / 23 Category: rheumatoid arthritis and gout Which of the following increases uric acid excretion? a. Allopurinol b. Aspirin c. Colchicine d. Probenecid 11 / 23 Category: rheumatoid arthritis and gout Which of the following is a DMARD? a. Desferrioxamine b. Penicillamine c. Succimer d. Dimercaprol 12 / 23 Category: rheumatoid arthritis and gout A drug X is useful in the treatment of rheumatoid arthritis. It is available only in parenteral formulation and its mechanism of action is antagonism of tumor necrosis factor. Which of the following can be X? a. Cyclosporine b. Penicillamine c. Phenylbutazone d. Etanercept Infliximab and etanercept are TNF-αantagonists useful for the treatment of rheumatoid arthritis. These are administered by parenteral route. TNF-α antagonists can cause reactivation of latent tuberculosis 13 / 23 Category: rheumatoid arthritis and gout A drug that is effective for rheumatoid arthritis but is not appropriate for osteoarthritis is a. Acetaminophen b. Infliximab c. Keterolac d. Rofecoxib It is a TNF-a antagonist that plays no role in osteoarthritis 14 / 23 Category: rheumatoid arthritis and gout Rasburicase is a newer drug used in gout. It act by: a. Decreasing urate synthesis b. Increasing urate oxidation c. Decreasing intestinal absorption of uric acid d. Increasing renal excretion of uric acid Rasburicase and pegloticase are recombinant urate oxidase enzymes that convert insoluble uric acid to soluble allantoin 15 / 23 Category: rheumatoid arthritis and gout Allopurinol is useful in all of the following conditions except: a. Cancer chemotherapy induced hyperuricemia b. Hydrochlorothiazide induced hyperuricemia c. Acute gouty arthritis d. Kala –azar llopurinol is contra-indicated in acute gout 16 / 23 Category: rheumatoid arthritis and gout Which of the following drugs is useful in chronic gout but is not a uricosuric agent? a. Probenecid b. Phenylbutazone c. Sulfinpyrazone d. Allopurinol 17 / 23 Category: rheumatoid arthritis and gout Most common dose limiting adverse effect of colchicine is: a. Sedation b. Kidney damage c. Diarrhea d. Muscle paralysis 18 / 23 Category: rheumatoid arthritis and gout Drug of choice for acute gout is a. Colchicine b. Indomethacin c. Allopurinol d. Dexamethasone NSAIDs except aspirin are the agents of choice for the treatment of acute gout 19 / 23 Category: rheumatoid arthritis and gout All of the following drugs can produce hyperuricemia except: a. Ethambutol b. Pyrazinamide c. Sulfinpyrazone d. Hydrochlorothiazide 20 / 23 Category: rheumatoid arthritis and gout Which of the following disease modifying antirheumatoid drugs is a prodrug? a. Etanercept b. Nimesulide c. Sulfasalazine d. Colchicine 21 / 23 Category: rheumatoid arthritis and gout Long term use of aspirin in rheumatoid arthritis is limited by its propensity to cause: a. Metabolic acidosis b. Hypersensitivity reactions c. Gastric mucosal damage d. Salicylism 22 / 23 Category: rheumatoid arthritis and gout Allopurinol prevents conversion of a. Hypoxanthine to xanthine b. Xanthine to hypoxanthine c. Hypoxanthine to I.M.P. d. Xanthine to uric acid e. both a & d Xanthine oxidase catalyses the conversion of hypoxanthine to xanthine as well as xanthine to uric acid. This enzyme is inhibited by allopurinol. 23 / 23 Category: rheumatoid arthritis and gout Which of the following drugs cause oligospermia? a. Leflunomide b. D-Penicillamine c. Methotrexate d. Sulfasalazine Your score is The average score is 50% LinkedIn Facebook Twitter VKontakte 0% Restart quiz ANTISEPTIC AND DISINFACTAN MCQ Quiz part IClick here for More MCQ QuizMutation & Its Types | MicrobiologyMedical Devices Act 2017 | Pharmacy NotesConcept of Health (WHO) | Social Pharmacy NotesAlligation Method in PharmaceuticsDefinition, History, Present Status and Scope of PharmacognosyNutrition – Macronutrients and Micronutrients Please leave this field empty Sign up to receive latest updates in your inbox. Email Address * You’ve been successfully subscribed to our newsletter!
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