GPAT Exam Paper 2023 with Answer Key

Q.81) Lignin is a complex polymer which can be stained pink in the tissue using the following chemicals

[a] Chloral Hydrate and Phloroglucinol

[b] Chlor-Zinc-Iodine

*[c] Phloroglucinol and hydrochloric acid

[d] Chloral Hydrate, Zinc and Ammonia

Q.82) Quinine and Quinidine differs in

[a] Chemical nature

[b] Molecular formula

*[c] Rotating the plane of polarized light

[d] Precursor of biosynthesis

Q.83) Which of the following ointment bases is an “Absorption base”

[a] Yellow ointment, USP

*[b] Hydrophilic petrolatum USP

[c] Hydrophilic ointment USP

[d] PEG ointment NF

Q.84) Match List I with List II

List 1List 2
NAME OF VITAMINFUNCTIONS OF VITAMINS
1. Riboflavin[P] The electron acceptor for isocitrate dehydrogenase
2. Niacin[Q] Decarboxylation of alpha-ketoglutarate dehydrogenase
3. Thiamine[R] Part of coenzyme A
4. Pantothenic acid [S] Cofactor for succinate dehydrogenase
 [T] Enzyme activity regular, such as for protein kinase C

Choose the correct answer from the options given below

*[a] 1-[S], 2-[P], 3-[Q], 4-[R]

[b] 1-[R], 2-[Q], 3-[S], 4-[T]

[c] 1-[P], 2-[R], 3-[S], 4-[Q]

[d] 1-[Q], 2-[T], 3-[P], 4-[S]

Q.85) E2 elimination converts neomenthyl chloride into a mixture of the following compounds

[a] 3-menthene (75%) and 2-menthene (25%)

*[b] 4-menthene (75%) and 2-menthene (25%)

[c] 3-menthene (25%) and 5-menthene (75%)

[d] 1-menthene (50%) and 3-menthene (50%)

Q.86) Which of the following is a tetracycline antidepressant that has additional Dopamine D₂ receptor blocking and neuroleptic properties as well as a greater tendency to cause seizure in overdose

*[a] Dothiepin

[b] Doxepin

[c] Trazodone

[d] Amoxapine

Q.87) Following is not an example of Carbapenem

[a] Thienamycin

[b] Imipenem

*[c] Piperacillin

[d] Meropenem

Q.88) A drug ‘X’ is more selective for the al subunit of BZD receptors. It lacks effect on slow-wave sleep. minimum residual daytime sedation, no rebound insomnia on

discontinuation, low abuse potential. Which of the following can be ‘X’

[a] Flurazepam

[b] Flumazenil

[c] Melatonin

*[d] Zolpidem

Q.89) What is the percentage of alcohol in a mixture obtained by mixing 5 L of 25%. 3 L of 40% and 2 L of 15% alcohol

*[a] 27.5% v/v

[b] 30.5% v/v

[c] 25.5% v/v

[d] 26.5% v/v

Q.90) Given below are two statements

Statement I: Levodopa is metabolized peripherally but capable of crossing Blood Brain Barrier, thus a best drug in treating Parkinsonism

Statement II: Carbidopa crosses Blood Brain Barrier, thus a best combination for protecting levodopa in CNS

In light of the above statements, choose the correct answer from the options given below

[a] Both Statement I and Statement II are true

[b] Both Statement I and Statement II are false

*[c] Statement I is true but Statement II is false

[d] Statement I is false but Statement II is true

Q.91) If the resins contain benzoic acids or cinnamic acids they are called

[a] Colophony

*[b] Balsams

[c] Glycoresins

[d] Resene

Q.92) Which of the following cranial nerve helps in accommodating the eye for near vision

*[a] Oculomotor

[b] Optic

[c] Trochlear

[d] Facial

Q.93) When is a New Drug Application (NDA) made

[a] Once the animal studies are done and drug is declared safe in animals

[b] Once the animal studies are done and drug is declared safe and effective in animal studies

*[c] After the phase III clinical trials

[d] After the phase IV clinical trials

Q.94) Which one is the right sequence of the intermediates in the biosynthesis of opium

alkaloids

I. Tyrosine

II. Reticuline

III. Codeine

IV. Morphine

V. Thebaine

Choose the correct answer from the options given below

[a] I, II, III, IV, V

*[b] I, II, V, III, IV

[c] I, II, V, IV, III

[d] I, II, IV, V, III

Q.95) Match the types of glycosides under Column I with their respective example under Column II and choose the correct option

COLUMN 1COLUMN 1
GLYCOSIDESEXAMPLES
1. Anthracene[P] Digitalis
2. Cardiac[Q] Licorice
3. Saponin[R] Senna
4. Cyanogenetic[S] Ashwagandha
 [T] Bitter almond

Choose the correct answer from the options given below

*[a] 1-[R], 2-[P], 3-[Q], 4-[T]

[b] 1-[T], 2-[P], 3-[Q], 4-[R]

[c] 1-[S], 2-[Q], 3-[P], 4-[R]

[d] 1-[Q], 2-[R], 3-[S], 4-[P]

Q.96) Lycopodium spores are used in quantitative microscopy for the following

I. Determine % purity of drugs

II. Estimation of percentage of foreign organic matter

III. Determination of palisade ratio

IV. Measurement of area of single layered tissue

Choose the correct answer from the options given below

[a] I, II and III only

[b] I, II and IV only

*[c] I only

[d] II and IV only

Q.97) Clear, sweetened hydroalcoholic solutions intended for oral use, usually flavoured to enhance their palatability are called

[a] Aromatic waters

*[b] Elixirs

[c] Syrups

[d] Tinctures

Q.98) Match the following cells of immune system List I with their functions List II

        LIST I                                         LIST II

IMMUNE SYSTEM                        FUNCTIONS

1. Mast cell                           [P] Master of Immune system

2. Lymphocytes                    [Q] Allergic reactions

3. T-cells                               [R] Cell mediated immune reaction

4. Monocytes-Macrophages [S] Antigen recognition, Phagocytosis

Choose the correct answer from the options given below

[a] 1-[P], 2-[Q], 3-[R], 4-[S]

*[b] 1-[Q], 2-[P], 3-[R], 4-[S]

[c] 1-[R], 2-[P], 3-[Q], 4-[S]

[d] 1-[P], 2-[R], 3-[Q], 4-[S]

Q.99) Which of the following is NOT an example of an mTOR inhibitor

[a] Everolimus

*[b] Tacrolimus

[c] Temsirolimus

[d] Sirolimus

Q.100) All the following are TNF-α Inhibitors EXCEPT

[a] Etanercept

[b] Infliximab

[c] Adalimumab

*[d] Basiliximab

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