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Q1: The earliest evidence that a drug is stored in tissue is
- An increase in plasma protein binding.
- A large apparent volume of distribution (VD).
- A decrease in the rate of formation of metabolites by the liver.
- An increase in the number of side effects produced by the drug.
Correct Ans: B
Q2: The renal clearance of inulin is used as a measurement of
- Rate of renal drug excretion.
- Intrinsic enzyme activity.
- Active renal secretion.
- Glomerular Filtration Rate (GFR).
Correct Ans: 4
Q3: All of the following classes of drugs are used to treat hypertension except
- Aryloxypropanolamines.
- thiazides.
- fibrates.
- dihydropyridines.
Correct Ans: 3
Q4: Which of the following drugs is considered to be the agent of choice for anaphylactic reactions?
- Clonidine
- Isoproterenol
- Epinephrine
- Phenylephrine
Correct Ans: 3
Q5: Opioids are used as all of the following agents except
- Antitussives.
- Analgesics.
- Anti-inflammatories.
- Antidiarrheals.
Correct Ans: 3
Q6: Which agent is most likely being used to treat his schizophrenic psychosis?
- clozapine
- fluoxetine
- buspirone
- risperidone
Correct Ans: 1
Q7: The termination of heparin activity by protamine sulfate is the result of
- A chelating action.
- The inhibition of gastrointestinal absorption of heparin.
- The displacement of heparin-plasma protein binding.
- An acid-base neutralization.
Correct Ans: 4
Q8: Cardiac glycosides may be useful in treating all of the following conditions except
- Atrial flutter.
- Paroxysmal atrial tachycardia.
- Congestive heart failure.
- Ventricular tachycardia.
Correct Ans: D
Q9: Which of the following classes of compounds stimulate the release of insulin from pancreatic cells?
- Biguanides
- Glucosidase inhibitors
- Sulfonylureas
- None of the above
Correct Ans: 3
Q10: The selective cyclooxygenase (COX) 2 inhibitors have been associated with which of the following adverse drug reactions?
- Severe ischemic colitis
- torsade des pointes
- Cardiovascular thrombotic events
- Acute liver failure
Correct Ans: 3
Q11: The schedule related to GMP for pharmaceutical products in Drugs and Cosmetics Act is
- Schedule L1
- Schedule Y
- Schedule M
- Schedule P
Correct Ans: 3
Q12: p-nitro benzoic acid is used as the starting material for the synthesis of
- Procaine
- Barbitone
- Imipramine
- Amitryptiline
Correct Ans: 1
Q13: The commonly accepted organic additives to local anesthetics to improve the duration of activity are:
- Skin penetration enhancers
- Vasoconstrictors
- Vasodialtors
- Antihistamines
Correct Ans: 2
Q14: The following is a selective PDE3 inhibitor
- Cilostozol
- Zafirlukast
- Rolipram
- Sildenafil
Correct Ans: 1
Q15: Guidelines for permission to import or manufacture of drugs for sale or to undertake clinical trials are laid down in the following schedule of Drugs and Cosmetics Act
- Schedule L1
- Schedule P
- Schedule Y
- Schedule H
Correct Ans: 3
Q16: In a patient weighing 70 kg, acetaminophen has a Vd of 70 L and CL of 350 mL/min. The elimination half life of drug is approximately
- 35 min
- 70 min
- 140 min
- 280 min
Correct Ans: 3
Q17: Urination in the human subject is decreased by
- Acetylcholine
- Benztropine
- Nicotine
- Phytostigmine
Correct Ans: 2
Q18: Which of the following drugs is most likely to cause severe symptoms of depression when used in treating hypertensive patients?
- Reserpine
- Prazosin
- Nifedipine
- Captopril
Correct Ans: 1
Q19: The prohibition of misbranded advertisement related to drugs falls under the following act
- Opium Act 1878
- Drugs and Magic Remedies Act 1954
- Dangerous Drugs Act 1930
- Essential Commodities Act, 1955
Correct Ans: 2
Q20: Lorazepam can be used as pre anesthetic medication in patients undergoing liver transplantation because the drug is
- Excreted in unchanged form
- Actively secreted into GI tract
- conjugated/metabolized extrahepatically
- None of the above
Correct Ans: 3
Q21: High level of resistance of M.tuberculosis to Isoniazid (INH) involves
Decreased intracellular accumulation of drug
Reduced expression of gene that encodes catalase
Inactivation of drug
Increased synthesis of mycolic acids
Correct Ans: B
Q22: Phenobarbitone belongs to the class of
Schedule X
Schedule R
Schedule O
Schedule Y
Correct Ans: A
Q23: Which of the following drugs used in Rheumatoid Arthritis has a mechanism of decreasing Tumor Necrosis
Factor?
Etanercept
Sulfasalazine
Rofecoxib
Pencillamine
Correct Ans: A
Q24: The following schedule deals with the life period of drugs:
Schedule L1
Schedule R
Schedule P
Schedule Y
Correct Ans: C
Q25: The most likely drug to be effective in diseases caused by cestodes and trematodes is
Chloroquine
Mebendazole
Metronidazole
Praziquantel
Correct Ans: D
Q26: The following acts as antiflatulent in the preparation of antacids
Selenium sulphide
Simethicone
sugar
Methyl paraben
Correct Ans: B
Q27: The following schedule refers to diseases or ailments for which a drug may not purport to prevent or cure:
Schedule G
Schedule R
Schedule J
Schedule X
Correct Ans: C
Q28: Precaution advisable when using lovastatin include
Serum transaminase measurements
Renal function tests
Acoustic measurements
Complete blood picture every month
Correct Ans: A
Q29: Government opium factory is situated at
Delhi
Bombay
Kasaouli
Neemuch
Correct Ans: D
Q30: The Ayurvedic and Unani poisons are listed in the following schedule
Schedule E1
Schedule F&F1
Schedule G
Schedule Y
Correct Ans: A
Q31: The oral liquid preparation specified in schedule X can be marketed in packing not exceeding:
100 ml
300 ml
25 ml
5 ml
Correct Ans: B
Q32: Carbimazole is
An antithyroid drug
An antiepileptic drug
A coagulant
An antihypertensive drug
Correct Ans: A
Q33: Neostigmine bromide is indicated primarily in the treatment of
Rheumatoid Arthritis
Myasthenia gravis
Convulsions
Brain stroke
Correct Ans: B
Q34: Schedule ‘S’ of the Drugs and Cosmetics Act, 1940 refers to:
Requirement of factory premises
List of poisons
Life period of drugs
Standard for cosmetics
Correct Ans: D
Q35: The absorption rate constant is calculated by:
Rate of excretion method
Wagner Nelson method
Michaelis Menten equation
Sigma Minus plot
Correct Ans: B
Q36: The loading dose (DL ) of a drug is usually based on the
Total body clearance (ClT) of the drug.
Percentage of drug bound to plasma proteins.
Fraction of drug excreted unchanged in the urine.
Apparent volume of distribution (VD) and desired drug concentration in plasma.
Correct Ans: D
Q37: Finasteride is approved for use in male pattern baldness and it acts as
Activator of estrogen receptors
Inhibitor of 5-alpha reductase
An aromatase inhibitor
An androgen receptor antagonist
Correct Ans: B
Q38: Which of the following drugs inhibits HMGCoA reductase?
Probucol
Lovastatin
Cofibrate
Gemfibrozil
Correct Ans: B
Q39: Which of the following drugs acts as an antihypertensive agent primarily by reduction of peripheral vascular resistance?
Diltiazem
Clonidine
Verapamil
Amlodipine
Correct Ans: D
Q40: ACE inhibitors are associated with high incidence of which of the following adverse reactions?
Hepatitis
Hypokalemia
Agranulocytosis
Proteinuria
Correct Ans: D
Q41: If digoxin has a half life of 35 hrs how long will it take for a toxic plasma concentration of 8ng/ml to decline to a therapeutic concentration of 2ng/ml?
17.5 hrs
70 hrs
105 hrs
140 hrs
Correct Ans: B
Q42: The initial distribution of a drug into tissue is determined chiefly by the
Rate of blood flow to the tissue
Stomach emptying time
Affinity of the drug to the tissue
Plasma protein binding of the drug.
Correct Ans: A
Q43: For which of the following product, measuring plasma concentration is not appropriate for estimating bioequivalence?
Enteric coated tablet containing NSAID
Suspension formulation containing analgesics
Metered dose inhalers containing a bronchodilator
Sustained release tablet antihypertensive drug.
Correct Ans: C
Q44: Which of the following compounded sterile product should not be prepared in a horizontal laminar flow hood?
Total Parenteral Nutrition
Dopamine
Cisplatin
Nitroglycerin
Correct Ans: C
Q45: Ezetimibe reduces cholesterol levels by
Inhibiting HMGCoA Reductase
Blocking or inhibiting intestinal absorption of cholesterol
Removes cholesterol from blood and stores in adipose tissue
Inducing lipoprotein lipase
Correct Ans: B
Q46: Amodiaquine, an antimalarial drug is synthesized from
Aniline
Anisole
Paracetamol
para nitrophenol
Correct Ans: C
Q47: The clearance of a I.V bolus injection in a patient weighing 50 kg is 4.9 liters and elimination rate constant is 0.5 hrs. The volume of distribution per kg of patient is
9.8 liters
98 liters
0.196 liters
0.98 liters
Correct Ans: C
Q48: Cytarabine is a natural analogue of
4-dihydrocytidine
4-deoxycytidine
2-deoxycytidine
2-dihydrocytidine
Correct Ans: C
Q49: The presence of electron withdrawing group on which position of phenothiazine is essential for its activity?
Second
Third
Fifth
Tenth
Correct Ans: A
Q50: The elimination rate constant of a drug by I.V bolus is 0.25 hrs. What is the half-life of the drug?
27.22 hrs
2.772 hrs
0.2772 hrs
2.772 min
Correct Ans: B
Q51: Chloroquine is prepared by condensing 4,7-dichloroquinoline with the following in phenol solution.
Pentamine
4 amino-1diethylaminopentane
Diethylamine
Hexamine
Correct Ans: B
Q52: Which of the following solvent is not used in IR Spectroscopy?
CCl4
CS2
CHCl3
H2O
Correct Ans: D
Q53: Drug of choice for filariasis is
Tinidazole
Piperazine
Diethylcarbamazine
Metronidazole
Correct Ans: C
Q54: Which of the following solvents has least eluting power?
Cyclohexane
Ethyl ether
Carbon tetrachloride
n-propanol
Correct Ans: A
Q55: The following is a potent inhibitor of CYP 450 enzymes
Cimetidine
Carbamazapine
Phenytoin
Phenobarbitone
Correct Ans: A
Q56: The standards for mechanical contraceptives are given in
Schedule R
Schedule S
Schedule T
Schedule U
Correct Ans: A
Q57: Benzidine test is used to detect
Glucose in urine
Blood in the urine
Albumin in serum
Uric acid in urine
Correct Ans: B
Q58: What is the most commonly used mulling agent in IR Spectroscopy?
CHCL3
Nuzol
Butadiene
Chlorohexane
Correct Ans: B
Q59: The overdose of atropine can be treated with
Deferoxamine
Physostigmine
Pralidoxime
Vitamin C
Correct Ans: B
Q60: The most important muscle useful for respiration is
Deltoid Muscle
Intercostal Muscle
Pectoralis major
Biceps
Correct Ans: B
Q61: Diacetlyl morphine is
Codeine
Apomorphine
Heroin
Oxymorphine
Correct Ans: C
Q62: The commonly used combination of preservatives for ophthalmic use is
Chlorobutanol and EDTA
Benzalkonium chloride and EDTA
Methy and propyl paraben
m-chlorocresol and methyl paraben
Correct Ans: B
Q63: The colligative properties of a solution are related to the following
Number of ions present in the solution
Number of solute particles
pH of the solution
Density of the solution
Correct Ans: B
Q64: The following heterocyclic ring is present in mepacrine, an anti malarial drug
Pteridine
Phenothiazine
Acridine
Phthalazine
Correct Ans: C
Q65: Mebendazole, an antigiradial agent, is a derivative of
Indoline
Benzimidazole
Indole acetic acid
Quinoline
Correct Ans: B
Q66: Tranexemic acid is a
Coagulant
Anti coagulant
Anti fibrinolytic
All of the above
Correct Ans: C
Q67: Caffeine is chemically
2,4,7-trimethyl xanthine
1,3,7-trimethyl xanthine
2,4,8-trimethyl xanthine
1,3,8-trimethyl xanthine
Correct Ans: B
Q68: Dragendroff’s reagent used for testing alkaloids is a solution of
Potassium mercuric chloride
Silver Nitrate
Potassium bismuth iodide
Sodium Chloride
Correct Ans: C
Q69: Prazosin is pharmacologically
a peripheral alpha-1 adrenergic blocker
An actibator of alpha 2 receptors
A beta blocker
An Angiotensin II Type I Receptor antagonist
Correct Ans: A
Q70: Which anticonvulsant drug requires therapeutic monitoring of Phenobarbital serum levels as well as its own serum level?
Phenytoin
Primidone
Clonazepam
Ethotoin
Correct Ans: B
Q71: The following is indicated as an adjunct to carbidopa/levodopa therapy:
Bromocriptine
Amantadine
Tolcapone
Pramipexole
Correct Ans: C
Q72:Which of the following disease modifying antirheumatic drugs can be administered orally?
Anakinra
Abatacept
Leflunomide
Etanercept
Correct Ans: C
Q73: For manufacturing of drugs other than those specified in schedule c and c1 and X, the licence is issued in the prescribed form no
25 A
25 B
25
25 F
Correct Ans: C
Q74: The antihypertensive drug that alters central sympathetic nervous system is
Propranolol
Clonidine
Nitroprusside
Captopril
Correct Ans: B
Q75: Potentiometric analysis is possible to estimate drugs that have
Chromophore group
Oxidation-reduction potential
Azo group only
Basic character
Correct Ans: B
Q76: The Drug Technical Advisory Board is reconstituted in every
5 years
2 years
3 years
4 years
Correct Ans: C
Q77: The HLB range for w/o emulsifying agent is
A 1-5
B 8-16
C 3-8
D 10-14
Correct Ans: C
Q78: The following preservative is used in the simple syrup I.P
Methyl Paraben
Phenyl mercuric nitrate
Benzalkonium Chloride
None of the above
Correct Ans: D
Q79: Acetaminophen toxicity is characterized by
Profound vasoconstriction and pain.
Severe abdominal cramping and diarrhea.
Central nervous system stimulation and seizures.
Profound liver damage and failure
Correct Ans: D
Q80: The following insulin preparation has longest duration of action
Semilente
Protamine zinc
Lente
Isophane
Correct Ans: B
Q81: Which district of Himachal Pradesh has the highest density of population (2011 census)?
Bilaspur
Una
Hamirpur
Solan
Correct Ans: C
Q82: According to 2010-11 agriculture census which district of Himachal Pradesh has the highest number of operational holdings?
Mandi
Kangra
Shimla
Una
Correct Ans: B
Q83: According to 2011 census which district of Himachal Pradesh has the highest rural literacy rate?
A Una
B Kangra
C Hamirpur
D Mandi
Correct Ans: C
Q84: Which district of Himachal Pradesh has the highest number of Muslims (2011 census)?
Chamba
Bilaspur
Sirmour
Shimla
Correct Ans: C
Q85: In which District of Himachal Pradesh is Kheerganga?
Shimla
Kullu
Chamba
Solan
Correct Ans: B
Q86: Near which town of Mandi District of Himachal Pradesh is Kalasar lake?
Pandoh
Chauntra
Rewalsar
Karsog
Correct Ans: C
Q87: In which district of Himachal Pradesh is Khokhan sanctuary?
Mandi
Kullu
Chamba
Una
Correct Ans: B
Q88: Taleru Sports complex is situated in district of Himachal Pradesh.
Bilaspur
Chamba
Mandi
Solan
Correct Ans: B
Q89: To which region of Himachal Pradesh did Satya Dev Bushahri belong?
Kumarsain
Rohru
Jubbal
Chopal
Correct Ans: B
Q90: Whose autobiography is titled Looking Back?
Narain Chand Prashar
Mohan Lal Aukta
Mehar Chand Mahajan
Kultar Chand Rana
Correct Ans: C
Q91: Where is Indian Military Academy (IMA) located?
Bengaluru
Dehradun
Kharagvasla
Kochi
Correct Ans: B
Q92: When was Rashtriya Madhyamic Shiksha Abhiyan launched?
2007
2008
2009
2010
Correct Ans: C
Q93: When did the new Bureau of Indian Standards Act come into force?
2014
2015
2016
2017
Correct Ans: D
Q94: Adolescent girls of which age group are covered under Kishori Shakti Yojna?
9 to 16
10 to 17
11 to 18
12 to 20
Correct Ans: C
Q95: Who headed the committee that recommended the de-regulation of sugar sector in India around 2013-14?
C. Rangarajan
Raghuram Rajan
C. Rangaswami
None of the above
Correct Ans: A
Q96: Around which year was declaration of independence adopted by the U.S. Continental Congress in Philadelphia?
1776
1789
1805
1809
Correct Ans: A
Q97: What is the capital of Peru?
Lima
Warsaw
Manila
Doha
Correct Ans: A
Q98: With which game is Cristiano Ronaldo associated?
Hockey
Cricket
Tennis
Football
Correct Ans: D
Q99: Earth Day is observed on April
- 22 january
- 22 March
- 22 April
- 22 may .
Correct Ans: 3
Q100: Which city of the world is known as the Windy City?
Chicago
London
Washington
Paris Correct
Ans: A
