DCO (DRUG CONTROL OFFICER) Solved Question Paper 2018 with Answer

21. Which of the following is opium?
a. The dried latex exudates of the unripe incised capsules
b. The dried aqueous extract of the ripe capsules
c. The dried alcoholic extract of the unripe capsules
d. concentrated alcoholic extract of the poppy straw

Answer with explanation

Ans: A

Biological source: Opium (Raw Opiunm) is the latex obtained by incision from the unripe
capsules of Papaver somniferum (Papaveraceae)
.

Phenanthrene group (Strong base nature)derivatives: Morphine, codeine, & Thebaine While Benzylisoquinolin derivative (feeble base) includes Noscapine, Narceine & Papaverine.

Meconic acid, a dibasic acid, is easily detected either in the free state or as a meconate by the formation of deep red colour on the addition of a solution of ferric chloride.

Morphine has depressant action on almost all organ except CTZ. (CTZ- Excitant- result into Vomiting).

22. Atropine is a 1:1 mixture of D and L-…
a. Scopoletin
b. Scopolamine
c. Hyoscyamine
d. Belladonnin

Answer with explanation

Ans: C

Belladonna root consists of the dried roots or rootstock and roots of Atropa belladonna (Solanaceae) & Atropine is the racemic mixture of l- and d-hyoscyamine and possesses 50% of the antimuscarinic potency of l-hyoscyamine.

 Atropine is also used in combination with other drugs as an antidote for poisonous anticholinesterase agents such as organophosphorus insecticides and neuroparalytic gases. In such situations, atropine removes or balances toxicities that are a result of a high concentration of acetylcholine.

23. Which of the following is the common skeleton of physiologically active ergoline
alkaloids?

a. Clavorubine
b. Isolysergic acid
c. 2-Phenylbenzopyran
d. Lysergic acid

24. Which of the following is the reagent for alkaloids?
a. 2,4-Dinitrophenylhydrazine
b. Iron(III)chloride
c. Antimony(III)chloride
d. Potassium tetra iodomercurate

25. Ergotoxine is a mixture of
a. 2 alkaloids
b. 3 alkaloids
c. 4 alkaloids
d. 6 alkaloids

26. Ergot powder gives blue color with
a. Benzaldehyde
b. P-dimethyl aminobenzaldehyde
c. Cinnamaldehyde
d. Formaldehyde

27. Which is not the chemical constituent naturally obtained from Opium?
a. Morphine
b. Codeine
c. Narcotine
d. Heroine

28. Palthe senna is identified with…
a. Absence of anthraquinone glycoside
b. Lamina is denser
c. Presence of anthraquinone glycoside
d. with tapering apex

29. Which is not the biological source of Cinchona?
a. Cinchona calisaya
b. Cinchona officinalis
c. Cinchona succirubra
d. Cinchona indica

30. Clove belongs to following family
a. Rubiaceae
b. Myrtaceae
c. Liliaceae
d. Rutaceae

31. The vitamin essential in the tissue culture medium is
a. Pyridoxine
b. Thiamine
c. Nicotinic acid
d. Inositol

32. Trukish opium is commonly known as
a. Chemist opium
b. Druggist opium
c. Chinese opium
d. Chemist and druggist

33. Bara Chandrika is synonym of
a. Rauwolfia tetraphylla
b. Rauwolfia vomitoria
c. Rauwolfia serpentina
d. Rauwolfia canacens

34. Which drug is under the chemical class of indole?
a. Senna
b. Cinnamon
c. Rauwolfia
d. Belladona

35. Vincristine act by which mechanism?
a. Inhibition of microtubule formation in mitotic spindle
b. suppresses the denovo biosynthesis of purines
c. inhibiting the production of THF
d. Immuno suppressant

36. Match the mode of action with antihypertensive drug
P. Block of β- adrenoceptors 1. Lisinopril
Q. ACE inhibition 2. Metoprolol
R. Arteriolar vasodilation 3. Amlodipine
S. Block of α1 adrenoceptors 4. Doxazocin
a. P-2, Q-3, R-4, S-1
b. P-1, Q-2, R-3, S-4
c. P-2, Q-1, R-3, S-4
d. P-4, Q-1, R-2, S-3

37. Adulterants of Rauwolfia serpentine are distinguished on the basis of:
a. Presence of sclerenchyma
b. Absence of sclerenchyma
c. Presence of parenchyma
d. Absence of parenchyma

38. Certain of the cells of the spongy Mesophyll are filled with microphenoidal (sandy) Crystals of calcium oxalate is characteristic of
a. Rauwolfia serpentina
b. Cinchona calisaya
c. Cassia acutifolia
d. Atropa belladonna

39. Which is not the use of Datura?
a. Anticholinergic
b. Mydriatic
c. Antiadrenergic
d. Control of Motion sickness

40. Entire parts of the following drugs are effective, except:
a. Ergot
b. Belladonna
c. Clove
d. Datura

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